Nainggolan was the headline omission when Roberto Martinez named his provisional 28-man party for Russia 2018, with the former Everton boss explaining his decision was made purely on tactical grounds.
It is the second time in the space of a year that the 30-year-old has called time on representing his country, having done so after being overlooked for last September’s World Cup qualifiers against Gibraltar and Greece.
He made an abrupt u-turn when named in the squad for November friendlies with Mexico and Japan but Nainggolan has now opted to rule himself out of future selection once again.
“Very reluctantly my international career comes to an end,” he wrote in an Instagram post.
“I’ve always done everthing [sic] I could to represent my country.
“Being yourself can be bothering. From this day on I will be the first fan.”