The former Real Madrid forward has struggled for form in the second half of his first campaign at Stamford Bridge, scoring 15 goals in 47 appearances for the Blues having joined for a club record £60 million ($80.5m) in the summer of 2017.
Morata has previously scored 13 goals in 23 appearances for La Roja, but the likes of Diego Costa, Iago Aspas and Rodrigo Moreno have been preferred by head coach Julen Lopetegui.
Spain’s full 23-man squad:
Goalkeepers: Kepa Arrizabalaga (Athletic Club), David de Gea (Manchester United), Pepe Reina (Napoli)
Defenders: Jordi Alba (Barcelona), Cesar Azpiliqueta (Chelsea), Dani Carvajal (Real Madrid), Nacho Fernandez (Real Madrid), Nacho Monreal (Arsenal), Alvaro Odriozola (Real Sociedad), Gerard Pique (Barcelona), Sergio Ramos (Real Madrid)
Midfielders: Thiago Alcantara (Bayern Munich), Sergio Busquets (Barcelona), Andres Iniesta (Barcelona), Isco (Real Madrid), Koke (Atletico Madrid), Saul Niguez (Atletico Madrid), David Silva (Manchester City)
Forwards: Marco Asensio (Real Madrid), Iago Aspas (Celta Vigo), Diego Costa (Atletico Madrid), Rodrigo Moreno (Valencia), Lucas Vazquez (Real Madrid).